Tropomyosin is a long, thin protein that helps regulate the interaction between actin and myosin filaments. It lies along the actin filaments and blocks the binding sites for myosin. When a nerve impulse triggers a muscle contraction, a molecule called calcium ions is released into the muscle cell. This causes troponin to bind to actin and move.. Action potentials in the motor neuron result in the release of acetylcholine, a neurotransmitter, at the neuromuscular junction. Acetylcholine binds to receptors on the muscle cell membrane, triggering an action potential in the muscle cell. This leads to the release of calcium ions into the cytoplasm, starting the process of muscle contraction.
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Nature Reviews Molecular Cell Biology 9, s6-s7 (2008) doi:10.1038/nrm2581. Goody, R. S. The missing link in the muscle cross-bridge cycle. Nature Structural Molecular Biology 10, 773-775 (2003.. How muscles contract – the sliding filament model. Muscles cause movement by contracting; During muscle contraction, sarcomeres within myofibrils shorten as the Z discs are pulled closer together This is known as the sliding filament model of muscle contraction and occurs via the following process:. An action potential arrives at the neuromuscular junction